Extra exocytosis rescues polarity
نویسندگان
چکیده
منابع مشابه
The caspase-related protease separase (extra spindle poles) regulates cell polarity and cytokinesis in Arabidopsis.
Vesicle trafficking plays an important role in cell division, establishment of cell polarity, and translation of environmental cues to developmental responses. However, the molecular mechanisms regulating vesicle trafficking remain poorly understood. Here, we report that the evolutionarily conserved caspase-related protease separase (extra spindle poles [ESP]) is required for the establishment ...
متن کاملLinking pore and pole
Extra exocytosis rescues polarity hang et al. (page 273) report a link between the exocyst and the t-SNAREs used for vesicle–plasma membrane fusion. The link comes in the form of Sro7p and Sro77p. These are yeast homologues of lethal giant larvae (Lgl), which was already known to bind t-SNAREs. Lgl is required for cell polarity and binds directly to t-SNAREs. Mutating Lgl induces polarity defec...
متن کاملExocytosis unbound.
The accepted theory of vesicular release of neurotransmitter posits that only a single vesicle per synapse can fuse with the membrane following action potential invasion, and this exocytotic event is limited to the ultrastructurally defined presynaptic active zone. Neither of these dictums is universally true. At certain synapses, more than a single vesicle can be released per action potential,...
متن کامل-regulated Exocytosis
Kinesin and myosin have been proposed to transport intracellular organelles and vesicles to the cell periphery in several cell systems. However, there has been little direct observation of the role of these motor proteins in the delivery of vesicles during regulated exocytosis in intact cells. Using a confocal microscope, we triggered local bursts of Ca 2 1 -regulated exocytosis by wounding the...
متن کاملmRNAs encoding polarity and exocytosis factors are cotransported with the cortical endoplasmic reticulum to the incipient bud in Saccharomyces cerevisiae.
Polarized growth in the budding yeast Saccharomyces cerevisiae depends upon the asymmetric localization and enrichment of polarity and secretion factors at the membrane prior to budding. We examined how these factors (i.e., Cdc42, Sec4, and Sro7) reach the bud site and found that their respective mRNAs localize to the tip of the incipient bud prior to nuclear division. Asymmetric mRNA localizat...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1702iti2